Communications orales

O01-2025
Applying the fragment-based drug design approach to the design of new anti-inflammatory compounds
Florian Schwalen, Charline Kieffer, Anne Sophie Voisin-Chiret
Young Research Fellows Meeting – Paris FR – Février 2025
 
O02-2025
Nanoémulsions combinant fénofibrate et oxydes de fer pour le traitement du glioblastome
Yasmine Chokry, Anne-Claire Groo, Sophie Corvaisier, Charly Hélaine, Aurélie Malzert-Fréon et Samuel Valable
17èmes journées scientifiques du Cancéropôle Nord-Ouest – Deauville FR – Mai 2025
 
O03-2025
In sillico studies of a membrane transporter involved in antibiotic resensitization
Côme Ghadi, Charline Kieffer, Johanna Giovannini, Peggy Suzanne, Aurélie Verneuil, Nicolas Verneuil, Axel Hartke, Alexandre Mahe and Jana Sopkova-De Oliveira Santos
GGMM 2025 – Forges-les-Eaux FR – Juin 2025
 
O04-2025
Exploiting targeted protein degradation via bivalent and monovalent degraders to uncover new therapeutic candidates against ovarian cancer
Lemaitre, T.; Kieffer, C.; Since, M.; Voisin-Chiret, A.S.
Journée de l’École Doctorale Normande de Chimie, 26 juin 2025, Le Havre.
 
O05-2025
Development and conformational analysis of innovative nitrogen-modified cyclotribenzylidene compounds
Château A, Dubost E, Fabis F
Journée de l’École Doctorale Normande de Chimie, 26 juin 2025, Le Havre.

O06-2025
Computational exploration of inhibitor candidates for a membrane transporter mediating antibiotic resensitization
Côme Ghadi
12èmes journées de la SFCI, 10-11 décembre 2025, Paris FR

O07-2025
Design, synthesis and biological evaluation of novel pan-inhibitors of matrix metalloproteinases as promotors of microglia polarization, with a potential interest in neurodegenerative diseases
Antoine MAGNIEZ
10^ème Drug Discovery Day, 12 décembre 2025, Lille FR

 
C05-2024

Design and synthesis of molecular hosts cryptophanes- application in imaging
Dubost, E.
Supr@Paris 3rd French Supramolecular Chemistry Congress, Paris, 15-17 May 2024
 
 
C06-2024

Targeted protein degradation, a groundbreaking strategy for drug discovery. Application to the degradation of the Mcl-1 protein as a promising route for developing novel cancer therapeutics
Voisin-Chiret, A.S.
TPD one-day symposium-Société de Chimie Thérapeutique-Sanofi, Gentilly (France), 30 mai 2024
 
 
C07-2024

Les Colles Moléculaires comme nouvelles stratégies thérapeutiques de dégradation ciblée de protéines
Voisin-Chiret, A.S.
Séance de la section 1 de l’Académie nationale de Pharmacie, Paris (France), 5 juin 2024
 
C08-2024
Targeted Protein degradation, an innovative approach in drug discovery
Voisin-Chiret, A.S.
International Conference and Exhibition on Pharmaceutical and Healthcare Sciences PHS 2024 , 5 juin 2024, Alexandrie (Egypte)
 
C09-2024
Design and evaluation of pleiotropic prodrugs able to modulate the serotonergic system in the context of Alzheimer’s disease
Rochais, C.
FAAST : France Alzheimer – Actualité Scientifiques et Thérapeutiques, Paris, 3 juin 2024
 
C10-2024
Advancing Neocopride: A Preclinical Candidate Multitarget Directed-Ligand (MTDL) for Neurodegenerative Disease Intervention
Rochais, C.
15th International Meeting on Cholinesterases – 9th International Conference on Paraoxonases (ChePON), Ljubjana (Slovenia), 15-18 Septembre 2024
 
C11-2024
Sérotonine et Alzheimer
Dallemagne, P.
Les lundi de l’IPSIT, Saclay, le 3 juin 2024
 
C12-2024
Inhiber l’interaction protéique XIAP/RIPK2 pour obtenir des molécules anti-inflammatoires.
Kieffer, C.
RECOB19, Aussois, 18-21 mars 2024
 
 C13-2024
UBE2N : une cible thérapeutique potentielle dans les cancers de l’ovaire ?
Kieffer, C., Weiswald, L.B.
2^ème journée scientifique de la SFNO, Caen, 15 octobre 2024

Discovery of an allosteric pocket network of the TrkB neurotrophin receptor, a promising target in the development of new ligands
Antonijevic, M., Bureau, R., Dallemagne, P., Rochais, C.
Journées jeunes chercheurs, Paris, 12.12 février 2021

Design et évaluation biologique d’inhibiteurs de Membrane-Type 5 Matrix Métalloprotéinase (MT5- MMP), d’intérêt thérapeutique potentiel dans le traitement de la maladie d’Alzheimer
Remondin, C., Davis, A., Rochais, C., Dallemagne, P.
Journées Nord-Ouest Européennes des Jeunes Chercheurs (JNOEJC), 10-11 juin 2021

Design of membrane-type 5 matrix metalloproteinase(MT5-MMP) inhibitors, of potential therapeutical interest in Alzheimer’s disease treatment
Rémondin, C., Davis, A., Legay, R., Bureau, R., Rochais, C., Dallemagne, P.
Journées de l’Ecole Doctorale Normande de Chimie, 24 Juin 2021

Application of cluster-based partitioning for structure-activity relationships in the BCR-ABL pharmacophore network
Geslin, D., Manguin, J.L., VO, N.V., Lepailleur, A., Cuissart, B., Bureau, R.
Journées de l’Ecole Doctorale Normande de Chimie, 24 Juin 2021

Synthesis and biological evaluation of novel pleiotropic prodrugs with therapeutic interest in Alzheimer’s disease
Travers–Lesage, V., Davis, A., Since, M., Dallemagne, P., Rochais, C.
Journées de l’Ecole Doctorale Normande de Chimie, 24 Juin 2021

Gold(I) mediated radio-iododecarboxylation of arenes
Bloux, H.
Journées de l’Ecole Doctorale Normande de Chimie, 24 Juin 2021

All for one and one for all, design and synthesis of molecules with neuronal differentiation properties
Antonijevic, M., Dallemagne, P., Rochais, C.
29th annual GP2A conference, online, 25-27 August 2021

Development of the first multi-target neurotrophin mimetics; a myth or a promising strategy in the battle against neurodegenerative disorders?
Antonijevic, M., Bureau, R., Dallemagne, P., Rochais, C.
“Neurotrophic Factors and Neurodegenerative Disorders; Current Advances and Future Perspectives”, Heraklion, 27-29 August 2021

New potent benzisoxazole derivatives as pleiotropic compounds with 5HT4R agonism and in cellulo antioxidant properties to fight Alzheimer’s disease
Lanthier, C., liparulo, I., Payan, H., Lecoutey, C., Since, M., Davis, A., Claeysen, S., Bolognesi, M.L., Dallemagne, P., Rochais, C.
27th Young Research Fellow Meeting , Caen, 29-31 Janvier 2020

Matrix metalloproteinases as new biological targets in Alzheimer’s disease: Opportunities and Challenges
Zipfel, P., Lalut, J., Denis, C., Bureau, R., Suzanne, P., Davis, A., Malzert-Fréon, A., Baranger, K., Khrestchatisky, M., Rivera, S., Rochais, C., Dallemagne, P.
27th Young Research Fellow Meeting , Caen, 29-31 Janvier 2020

Development of safe and brain-targeting nanovectors for Alzheimer’s disease treatment
Séguy, L., Groo, A.C., Maurel, M., Verdié, P., Dallemagne, P., Lisowski, V., Malzert-Fréon, A.
27th Young Research Fellow Meeting , Caen, 29-31 Janvier 2020

MR35806: a new fluorinated indazole compound as a potential 5-HT4R PET radiotracer
Mangeant, R., Stiebing, S., Cailly, T., Davis, A., Fabis, F., Collot, V.
27th Young Research Fellow Meeting , Caen, 29-31 Janvier 2020

Design, synthesis and characterization of small molecules as new Tau aggregation disruptors
Giovannini, J., Jouanne, M., Sopkova-De Oliveira Santos, J., Catto, M., Voisin-Chiret, A.S
27th Young Research Fellow Meeting , Caen, 29-31 Janvier 2020

Development of TrkB/5-HT4 receptors ligands, a new approach in the treatment of neurodegenerative diseases
Antonijevic, M., Charou, D., Rogdakis, T., Papadopoulou, M., Gravanis, A., Charalampopoulos, I., Dallemagne, P., Rochais, C.
27th Young Research Fellow Meeting , Caen, 29-31 Janvier 2020
Prix de la meilleure communication flash

In silico design and synthesis of original MT2R/5-HT2CR MTDLs as potential therapeutics for Alzheimer’s disease.
Thirumaran, S.L., Bureau, R., Lepailleur, A., Rochais, C.
27th Young Research Fellow Meeting , Caen, 29-31 Janvier 2020

Drug repositioning based on real life side effects, identifying unkown butyrylcholinesterase inhibitors useful in alzheimer’s disease treatment
Jourdan, J.P., Chrétien, B., Davis, A., Dolladille, C., Bureau, R., Fedrizzi, S., Lelong-Boulouard, V., Sassier, M., Alexandre, J., Rochais, C., Dallemagne, P.
27th Young Research Fellow Meeting , Caen, 29-31 Janvier 2020

Design of small protein-protein interaction disruptors to overcome apoptosis resistance
Guedeney, N., Antraygues, K., Jouanne, M., Sopkovà de Oliveira Santos, J., Voisin-Chiret, A.-S., Kieffer, C.
27th Young Research Fellow Meeting , Caen, 29-31 Janvier 2020

Exploring Brain – Immune interaction with hyper – polarized Xenon – 129 Magnetic Resonance Imaging
Vigier, C., Dubost, E., Vivien, D., Fernandez, C., Cailly, T., Fabis, F.
27th Young Research Fellow Meeting , Caen, 29-31 Janvier 2020

Synthèse d’inhibiteurs de MT5-MMP
Remondin, C., Rochais, C., Dallemagne, P.
Journées Scientifiques Francophone du CALM, Montpellier, 17-18 Novembre 2020

From 3D models of Tau protein aggregates to conception and synthesis of potential Tau aggregation disruptors
Giovannini, J., Jouanne, M., Sopkova-de Oliveira Santos, J., Voisin-Chiret, A.S.
Journées de l’Ecole Doctorale Normande de Chimie, November 26-27 2020

Exploring Brain –Immune interaction with hyper –polarized Xenon –129 Magnetic Resonance Imaging
Vigier, C., Dubost, E., Vivien, D., Fernandez, C., Cailly, T., Fabis, F.
Journées de l’Ecole Doctorale Normande de Chimie, November 26-27 2020

Development of innovative nanovectors for targeted brain delivery
Séguy, L., Groo, A.C., Guyon, L., Corvaisier, S., Davis, A., Maurel, M., Verdié, P., Dallemagne, P., Lisowski, V., Malzert-Fréon, A.
Journées de l’Ecole Doctorale Normande de Chimie, November 26-27 2020

Multi-target neurotrophin receptors ligands, an emerging strategyin the treatment of neurodegenerative diseases
Antonijevic, M., Charou, D., Rogdakis, T., Papadopoulou, M., Gravanis, A., Charalampopoulos, I., Dallemagne, P., Rochais, C.
Journées de l’Ecole Doctorale Normande de Chimie, November 26-27 2020
Prix de la meilleure communication orale des JEDNC

Development of small molecules neurotrophin mimetics, an emerging strategy in the treatment of neurodegenerative disorders
Antonijevic, M., Charou, D., Rogdakis, T., Papadopoulou, M., Gravanis, A., Charalampopoulos, I., Dallemagne, P., Rochais, C.
Drug Discovery Day, Lille, 16 Décembre 2020

Nanoemulsion as a useful tool for drug development
Séguy, L., Groo, A.C., Malzert-Fréon, A.
Formulation days, Lyon, 10-11 Janvier 2019

Design and synthesis of new polypharmacological compounds with antioxidant properties in Alzheimer’s disease
Lanthier, C., Lecoutey, C., Lalut, J., Since, M., Davis, A., Dallemagne, P., Bolognesi, M.L., Rochais, C.
Drug Discovery Day, Lille, 18 Janvier 2019.

Synthesis and biological evaluation of multi-target directed ligands as potential treatment for alzheimer’s disease
Hatat, B., Lecoutey, C., Davis, A., Freret, T., Boulouard, B., Rochais, C., Claeysen, S., Dallemagne, P.
26th Young Research Fellow Meeting , Paris (France), 20-22 Février 2019

Alzheimer’s Disease: Development and application of a Multistep Procedure to Characterize Modulators of Amyloid Peptide Aggregation
Smeralda, W., Since, M., Jourdan, J.P., Corvaisier, S., Boisserie, M., Cardin, J., Rochais, C., Dallemagne, P., Malzert-Fréon, A.
26th Young Research Fellow Meeting , Paris (France), 20-22 Février 2019

Development of novel MTDL combining 5-HT4R agonism and antioxidant properties in Alzheimer’s disease
Lanthier, C., Lecoutey, C., Lalut, J., Since, M., Davis, A., Dallemagne, P., Bolognesi, M.L., Rochais, C.
3rd WG meeting – Activities of young investigators within the WG MuTaLig COST Action – Paris (France) 23-24 February 2019

Polypharmacology in Alzheimer’s Disease: innovative MTDLs combining 5-HT4R agonism and promising in cellulo antioxidant activities
Lanthier, C., Payan, H., Liparulo, I., Lalut, J., Since, M., Davis, A., Dallemagne, P., Claeysen, S. Bolognesi, ML., Rochais, C.
Journée Scientifique de la FR INC3M, Rouen, 24 Juin, 2019

Conception, synthèse et évaluation biologique de (pro)drogues pléiotropes IMAO-B/IAChE d’intérêt thérapeutique dans la maladie d’Alzheimer
Guieu, B., Rochais, C., Dallemagne, P.
Journée Scientifique de la FR INC3M, Rouen, 24 Juin, 2019

Detection of Vancomycin Resistance through D-Alanine-D-Alanine dipeptidasique activity
Ouedraogo, W., Fossey, C., Cattoir, V., Cailly, T., Fabis, F.
Journée de l’Ecole Doctorale Normande de Chimie, Caen, 5 Juilllet, 2019

Synthesis and biological evaluation of original bicyclic thiophene derivatives targeting MT5-MMP for Alzheimer’s therapy
Zipfel, P., Lalut, J., Denis, C., Bureau, R., Suzanne, P., Davis, A., Malzert-Fréon, A., Baranger, K., Khrestchatisky, M., Rivera, S., Rochais, C., Dallemagne, P.
Journée de l’Ecole Doctorale Normande de Chimie, Caen, 5 Juilllet, 2019
Prix de la meilleure communication orale

Alzheimer’s Disease: Development and application of a Multistep Procedure to Characterize Modulators of Amyloid Peptide Aggregation
Smeralda, W., Since, M., Jourdan, J.P., Corvaisier, S., Duprey, S., Cardin, J., Rochais, C., Dallemagne, P., Malzert-Fréon, A.
Journée de l’Ecole Doctorale Normande de Chimie, Caen, 5 Juilllet, 2019

Access to new diagnostic tools in oncology through a mild radioiododesilylation process
Hebert, A., Babin, A., Benoist, F., Dubost, E., Fabis, F., Cailly, T.
Journée de l’Ecole Doctorale Normande de Chimie, Caen, 5 Juilllet, 2019

Polypharmacological compounds in Alzheimer’s Disease: innovative 5-HT4R agonist with promising in cellulo antioxidant properties
Lanthier, C., liparulo, I., Payan, H., Lecoutey, C., Since, M., Davis, A., Claeysen, S., Bolognesi, M.L., Dallemagne, P., Rochais, C.
GP2A 2019 – 27th Annual GP2A Medicinal Chemistry Conference – Nottingham UK, 21st – 23rd August 2019

Combining structure-based and ligand-based approaches for the design of new MTDLs with potential interest for Alzheimer’s disease
Thirumaran, S.L., Bureau, R., Lepailleur, A., Rochais, C.
9e journées de la SFCi, Paris, 21-22 Novembre 2019

Design of new non-peptide foldamers of SMAC
Giret, M., Antraygues, K., Yahia-Ouahmed, M., Jouanne, M., Kieffer, C., Sopkova-de Oliveira Santos, J.
9e journées de la SFCi, Paris, 21-22 Novembre 2019

Mcl-1 structural dynamics from protein ensembles, enhanced sampling and pocket crosstalk analysis
Benabderrahmane, M., Voisin-Chiret, A.S, Bureau, R., Sopkova-de Oliveira Santos. J
9e journées de la SFCi, Paris, 21-22 Novembre 2019

In silico Tau aggregates as tool for design and synthesis of aggregation disruptors related to Alzheimer’s Disease
Giovannini, J., Sopkova-De Oliveira Santos, J., Catto, M., Voisin-Chiret, A.S
9e journées de la SFCi, Paris, 21-22 Novembre 2019

Intérêt des liposomes en tant que modèle membranaire afin de déterminer le coefficient de partage d’un candidat-médicament : le Pyridoclax
Smeralda, W., Since, M., Corvaisier, S., Voisin-Chiret, A.S., Malzert-Fréon, A.
Nanoday 2018, Journée Normande de la nano-caractérisation, Caen, 8 Février 2018

Exploring Chemical Space with 3,3-Diarylazetidine Derivatives Towards the Discovery of Anti-Apoptotic Protein Inhibitors
Denis, C., Dubois, M., Voisin-Chiret, A.S., Bureau, R., Bull, J.A.
25th Young Research Fellow Meeting , Orléans (France), 5-7 Mars 2018

Synthesis and biological evaluation of novel concept: prodrugs with multi-target activites in Alzheimer’s disease
Toublet, F.X., Lalut, J., Lecoutey, C., Davis, A., Rochais, C., Dallemagne, P.
25th Young Research Fellow Meeting , Orléans (France), 5-7 Mars 2018

Searching for new dual inhibitors of anti-apoptotic members of Bcl-2 family for the treatment of chemoresistant ovarian cancer
De Pascale, M., Denis, C., Marekha, B., Brotin E., Poulain L., Voisin-Chiret A.S.
25th Young Research Fellow Meeting , Orléans (France), 5-7 Mars 2018

Administration par voie intranasale d’un principe actif hydrophile d’intérêt thérapeutique potentiel dans le traitement de la maladie Alzheimer
Adnet, T., Groo, A.C., Le Pluart, L., Picard, C., Corvaisier, S., Since, M., Rochais, C., Dallemagne, P., Malzert-Fréon, A.
Hopipharm 2018, Congrès francophone de pharmacie hospitalière, Bordeaux, 16-18 mai 2018

Conception de perturbateurs d’interactions protéine-protéine agissants sur l’apoptose cellulaire pour le traitement des cancers de l’ovaire chimiorésistants
De Pascale, M., Denis, C., Marekha, B., Brotin E., Poulain L., Voisin-Chiret A.S.
17èmes Rencontres de Chimie Organique et Biologique (RECOB), Aussois (France), 18-22 Mars 2018

Conception and synthesis of novel MT5-MMP inhibitors for Alzheimer’s disease
Zipfel, P., Lalut, J., Giovannini, J., Saidouna, H., Suzanne, P., Lepailleur, A., Bureau, R., Baranger, K., Khrestchatisky, M., Rivera, S., Rochais, C., Dallemagne, P.
GP2A-JFB 208 International conference on Medicinal Chemistry, Asnelles, 13-15 June 2018

Fast detection of Vancomycin Resistance
Ouedraogo, W., Fossey, C., Cattoir, V., Cailly, T., Fabis, F.
GP2A-JFB 208 International conference on Medicinal Chemistry, Asnelles, 13-15 June 2018

Docking studies of melatonergic and serotonergic Multi-Target Directed Ligands of potential interest for Alzheimer’s disease
Thirumaran, S.L., Xiao, F., Lemaître, S., Bureau, R., Rault, R., Lepailleur, A., Rochais, C.
GP2A-JFB 208 International conference on Medicinal Chemistry, Asnelles, 13-15 June 2018

Fluorinated indazole derivatives: promising structures for 5-HT4 receptors PET radiotracers
Mangeant, R., Stiebing, S., Cailly, T., Davis, A., Fossey, C., Fabis, F., Collot, V.
GP2A-JFB 208 International conference on Medicinal Chemistry, Asnelles, 13-15 June 2018
Prix de la meilleure communication orale

Conception and synthesis of new pleiotropic compounds that both display 5-HT4R agonist activity and antioxidant property in Alzheimer’s disease
Lanthier, C., Lecoutey, C., Lalut, J., Toublet, F.X., Dallemagne, P., Rochais, C.
GP2A-JFB 208 International conference on Medicinal Chemistry, Asnelles, 13-15 June 2018

Synthesis of serotonergic Multi-Target Directed Ligands as new drugs for Alzheimer’s Disease
Hatat, B., Lecoutey, C., Davis, A., Freret, T., Boulouard, B., Ismeurt, C., Rochais, C., Claeysen, S., Dallemagne, P.
GP2A-JFB 208 International conference on Medicinal Chemistry, Asnelles, 13-15 June 2018

Mcl-1 selective inhibitor modulation: discovery of Mcl-1/Bcl-xL dual inhibitors, for the treatment of chemoresistant ovarian cancers
De Pascale, M., Denis, C., Brotin, E., Poulain, L., Voisin-Chiret, A.S.
GP2A-JFB 208 International conference on Medicinal Chemistry, Asnelles, 13-15 June 2018

Design and synthesis of new iodinated diazaphenanthridines as potent 5-HT4R SPECT radiotracers
Babin, V.; Cailly, T.; Bouillon, J.P.; Fabis, F.
24th Young Research Fellow Meeting , Chatenay-Malabry (France), 8-10 Février 2017

Design, synthesis and evaluation of new iodinated diazaphenanthridines : application to the developement of new potential 5-HT4R SPECT radiotracers
Babin, V.; Tournier, B.; Davis, A.; Millet, P.; Cailly, T.; Bouillon, J-P.; Fabis, F
Journées Nord-Ouest Européennes des Jeunes Chercheurs et du Groupe Français des Polymères Grand Ouest, 9-10 juin 2017, Caen (France)

Synthesis of original serotonergic Multi-Target Directed Ligands – The TRIAD program
Hatat, B., Lecoutey, C., Yahiaoui, S., Davis, A., Freret, T., Boulouard, M., Claeysen, S., Rochais, C., Dallemagne, P.
25th Annual GP2A Medicinal Chemistry Conference, Liverpool (UK), 31 August – 1 September 2017

From the design to the in vitro evaluation of new iodinated diazaphenanthridine for the development of potential 5-HT4 SPECT radiotracer
Babin, V.
25th Annual GP2A Medicinal Chemistry Conference, Liverpool (UK), 31 August – 1 September 2017

Synthesis and biological evaluation of prodrugs with acetylcholinesterase inhibition and 5-HT4 Receptor agonist activities targeting Alzheimer’s disease
Toublet, F.X., Lecoutey, C., Davis, A., Rochais, C., Dallemagne, P.
31èmes Journées Franco-Belge de Pharmacochimie, Spa (Belgique), 14 – 15 Septembre 2017

Synthesis of original serotonergic Multi-Target Directed Ligands – The TRIAD program
Hatat, B., Lecoutey, C., Yahiaoui, S., Davis, A., Freret, T., Boulouard, M., Claeysen, S., Rochais, C., Dallemagne, P.
31èmes Journées Franco-Belge de Pharmacochimie, Spa (Belgique), 14 – 15 Septembre 2017

Fragment-Based Drug Discovery targeting inhibitor of apoptosis proteins
Denis, C.; Legay, R.; Bureau, R.;Voisin-Chiret, A.S.
31èmes Journées Franco-Belge de Pharmacochimie, Spa (Belgique), 14 – 15 Septembre 2017
Prix de la meilleure communication orale

Selective functionalization of the indazole scaffold, application to the synthetis of new 5-HT7R SPECT radioligands
Berhault, Y.; Lam, B. V.; Fossey, C.; Stiebing, S.; Cailly, T.; Collot, V.; Fabis, F
23rd Young Research Fellow Meeting , Lille (France), 15-17 Février 2016

Pfrab6 and PfpyrK1 as potential plasmodial targets of 4-anilino-2-trichloromethylquinazolines
Kieffer, C., Verhaeghe, P., Reininger, L.; Bach, S.; Renault, J.; Merckx, A.; Doerig, C.; Hutter, S.; Uriac, P.; Laget, M.; Azas, N.; Rault, S.; Langsley, G.; Rathelot, P.; Vanelle, P.
23rd Young Research Fellow Meeting , Lille (France), 15-17 Février 2016
Prix « Best Flash Poster Presentation » décerné par la « Royal Society of Chemistry »

Design, co-crystallization and biological evaluation of novel Multi-Target-Directed Ligand targeting acetylcholinesterase and sigma-1 receptors of potential interest for Alzheimer’s disease treatment
Lalut, J.; Karila, D.; Ballandonne, C.; Davis, A.; Santoni, G.; Weik, M.; Dallemagne, P.; Rochais, C.
23rd Young Research Fellow Meeting , Lille (France), 15-17 Février 2016

Acetylcholinesterase as a novel target against the parasite Varroa destructor
Riva, C.; Sopkova-de Oliveira Santos, J.; Halm-Lemeille, M.P.
19èmes journées de l’école doctorale EdNBISE, Caen, 10-11 Mars 2016.

Functionalization of the indazole scaffold, application to the synthetis of new 5-HT7R SPECT radioligands
Berhault, Y.; Lam, B. V.; Fossey, C.; Stiebing, S.; Cailly, T.; Collot, V.; Fabis, F
Rencontres de Chimie Organique et Biologique , Aussois (France), 13-17 Mars 2016.

Fragment-Based Drug Design of a Series of Mcl-1/Bcl-xL Dual Inhibitors used in the Treatment of Chemoresistant Ovarian Cancers
Denis, C. ; Legay, R. ; Bureau, R. ; Voisin-Chiret A.S.
13th Anglo-Norman colloquium on organic chemistry, Rouen, 24-27 Avril 2016.

Des nanoémulsions comme stratégie de solubilisation d’un agent thérapeutique innovant pour le traitement des cancers de l’ovaire
Groo, A.C.; Since, M.; Hedir, S.; Poulain, L.; Voisin-Chiret, A.S.; Malzert-Fréon, A.
9èmes journées scientifiques du Cancéropôle Nord-Ouest, Deauville (France), 18 – 20 Mai 2016.

Quantile de régression séquentielle : application à l’étude du mode d’action des composés chimiques
Bureau, R., Durieu, G. et Villain, J.
48èmes journées de statistique de la société française de statistique, Montpellier, 2 juin 2016.

New Series of Mcl-1/Bcl-xL Dual Inhibitors for the Treatment of Chemoresistant Ovarian Cancers
Denis, C. ; Legay, R. ; Bureau, R. ; Voisin-Chiret A.S.
24th conference of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Angers, 25-26 août 2016.

Norns : Un outil logiciel pour la chemoinformatique
Bureau, R. ; Cuissart, B. ; Lepailleur, A. ; Métivier, J.P.
Journée NormanDev « Cycle de vie du logiciel », Caen, 8 décembre 2016

Découverte du mécanisme d’action de nouveaux agents antiplasmodiaux
Kieffer, C.
8èmes journées scientifiques de l’UFR des Sciences Pharmaceutiques, Caen, 10 Novembre 2016

Synthesis of an iodinated ligand analogue of GR-113808 as a potent 5-HT4R SPECT radiotracer
Lefol, L-A., Babin, V.; Davis, A.; Cailly, T.; Bouillon, J-P.; Fabis, F.
8èmes journées scientifiques de l’UFR des Sciences Pharmaceutiques, Caen, 10 Novembre 2016

Cyclic peptide hormones: Conformation, dynamics and pharmacophores of Urotensin and Vasopresin.
Delépée, C.; Haensele, E.; Mele, N.; Saleh, N.; Whitley, D.; Read, C.; Cary, P.; Lepailleur, A.; Sopkova-de Oliveira Santos, J.; Castel, H.; Milazzo, I.; Bureau, R.; Essex, J.; Banting, L.; Clark, T.
Peptide Research Network of Excellence (PeReNE) Final Meeting, Le Havre (France), 15-16 Janvier 2015.

Development of Multi-Target Directed Ligands with pronostic and/or therapeutic effects in Alzheimer’s disease
Lalut, J.; Dallemagne, P.; Rochais, C.
Closing Event INTERREG IVA AI CHEM, Rouen, 19 Janvier 2015

New antimalarial flavones: from screening to in vivo proof of concept
Nardella, F.; Collot, V.; Stiebing, S.; Kaiser, M.; Schmitt, M.; Candolfi, E.; Vonthron-Sénécheau, C.
Journées Campus d’Illkich, Strasbourg, 13-14 Avril 2015

Donecopride, a newly designed MTDL, appears as a promising candidate for the treatment of Alzheimer’s disease
Hamidouche, K.; Bouet, V.; Dallemagne, P.; Rochais, C.; Lecoutey, C.; Freret, T.; Boulouard, M.
19ème Congrès SFPT, Caen, 21-23 Avril 2015.

Design, Synthesis and Biological Evaluation of Novel Benzisoxazole Derivatives with Acetylcholinesterase Inhibitory and Serotoninergic 5-HT4 Receptor Agonist Activities for the Treatment of Alzheimer’s
Lalut, J.; Lecoutey, C.; Davis, A.; Legay, R.; Sopkova de Oliveira Santos, J.; Dallemagne, P.; Rochais, C.
Journées de l’Ecole Doctorale Normande de Chimie couplée – Journées Nord-Ouest Européennes des Jeunes Chercheurs, Rouen, 11 et 12 Mai 2015.

Polysubstituted indazoles, application to the synthesis of 5-HT7R SPECT radiotracers
Berhault, Y.; Lam, B.-V.; Fossey, C.; Stiebing, S.; Cailly, T.; Collot, V.; Fabis, F.
Journées de l’Ecole Doctorale Normande de Chimie couplée – Journées Nord-Ouest Européennes des Jeunes Chercheurs, Rouen, 11 et 12 Mai 2015.

Impacts des résidus médicamenteux au niveau aquatique
Halm, M.P.; Minguez, L.; Serpentini, A.; Lebel, J.M.; Bureau, R.; Bidel, F.; Bellanger, C.; Budszinsky, H.; Cossu, C.
SEFA, Bordeaux, 31 Juin – 1er Juillet 2015.

Selective functionalization of the indazole scaffold, application to the synthesis of 5-HT7R SPECT radiotracers
Berhault, Y.; Lam, B. V.; Cailly, T.; Fossey, C.; Stiebing, S.; Fabis, F.; Collot, V.
1st European Conference on Therapeutic Targets and Medicinal Chemistry, Münster (Germany), 26-27 Aout 2015,

Fonctionalisation selective de l’indazole : application à la synthèse de radiotraceurs SPECT du récepteur 5-HT7
Berhault, Y.; Lam, B. V.; Cailly, T.; Fossey, C.; Stiebing, S.; Fabis, F.; Collot, V.
Journée Scientifique l’UFR des Sciences Pharmaceutiques, 5 novembre 2015, Caen (France)