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Publications 2020

(206)     Séguy, L.; Groo, A.-C.; Goux, D.; Hennequin, D.; Malzert-Fréon, A. Design of Non-Haemolytic Nanoemulsions for Intravenous Administration of Hydrophobic APIs. Pharmaceutics 2020, 12 (12), 1141.

(205)     Kieffer, C.; Jourdan, J. P.; Jouanne, M.; Voisin-Chiret, A. S. Noncellular Screening for the Discovery of Protein–Protein Interaction Modulators. Drug Discov. Today 2020, 25 (9), 1592–1603.

(204)     Zipfel, P.; Rochais, C.; Baranger, K.; Rivera, S.; Dallemagne, P. Matrix Metalloproteinases as New Targets in Alzheimer’s Disease: Opportunities and Challenges. J. Med. Chem. 2020, 63 (19), 10705–10725.

(203)     Thieulent, C.; Hue, E.; Sutton, G.; Fortier, C.; Dallemagne, P.; Zientara, S.; Munier-Lehmann, H.; Hans, A.; Paillot, R.; Vidalain, P.; Pronost, S. Identification of Antiviral Compounds against Equid Herpesvirus-1 Using Real-Time Cell Assay Screening: Efficacy of Decitabine and Valganciclovir Alone or in Combination. Antiviral Res. 2020, 183, 104931.

(202)     Coulibaly, S.; Cimino, M.; Ouattara, M.; Lecoutey, C.; Buchieri, M. V; Alonso-Rodriguez, N.; Briffotaux, J.; Mornico, D.; Gicquel, B.; Rochais, C.; Dallemagne, P. Phenanthrolinic Analogs of Quinolones Show Antibacterial Activity against M. Tuberculosis. Eur. J. Med. Chem. 2020, 207, 112821.

(201)     Camacho, E.; Marie, N.; Dupas, Q.; Martel, C.; Nowoczyn, M.; Elie, N.; Rochais, C.; Töth, G.; Allouche, S. Impact of T161, Y318 and S363 Alanine Mutations on Regulation of the Human Delta-Opioid Receptor (HDOPr) Induced by Peptidic and Alkaloid Agonists. Neuropharmacology 2020, 179, 108286.

(200)     Bourafai-Aziez, A.; Sebban, M.; Benabderrahmane, M.; Marekha, B.; Denis, C.; Paysant, H.; Weiswald, L. B.; Carlier, L.; Bureau, R.; Coadou, G.; Ravault, D.; Voisin-Chiret, A.S.; Sopkova-de Oliveira Santos, J., Oulyadi, H. Binding Mode of Pyridoclax to Myeloid Cell Leukemia-1 (Mcl-1) Revealed by Nuclear Magnetic Resonance Spectroscopy, Docking and Molecular Dynamics Approaches. J. Biomol. Struct. Dyn. 2020, 38 (14), 4162–4178.

(199)     Fersing, C.; Boudot, C.; Paoli-Lombardo, R.; Primas, N.; Pinault, E.; Hutter, S.; Castera-Ducros, C.; Kabri, Y.; Pedron, J.; Bourgeade-Delmas, S.; Sournia-Saquet, A.; Stigliani, J.L.; Valentin, A.; Azqueta, A.; Muruzabal, D.; Destere, A.;Wyllie, S.; Fairlamb, A.H.; Corvaisier, S.; Since, M.; Malzert-Fréon, A.; Di Giorgio, C.; Rathelot, P.; Azas, N.; Courtioux, B.; Vanelle, P.; Verhaeghe, P. Antikinetoplastid SAR Study in 3-Nitroimidazopyridine Series: Identification of a Novel Non-Genotoxic and Potent Anti-T. b. Brucei Hit-Compound with Improved Pharmacokinetic Properties. Eur. J. Med. Chem. 2020, 206, 112668.

(198)     Groo, A. C.; Hedir, S.; Since, M.; Brotin, E.; Weiswald, L.-B.; Paysant, H.; Nee, G.; Coolzaet, M.; Goux, D.; Delépée, R.; Freret, T.; Poulain, L.; Voisin-Chiret, A.S.; Malzert-Fréon, A. Pyridoclax-Loaded Nanoemulsion for Enhanced Anticancer Effect on Ovarian Cancer. Int. J. Pharm. 2020, 587 (December 2019), 119655.

(197)     Lanthier, C.; Dallemagne, P.; Lecoutey, C.; Claeysen, S.; Rochais, C. Therapeutic Modulators of the Serotonin 5-HT 4 Receptor: A Patent Review (2014-Present). Expert Opin. Ther. Pat. 2020, 30 (7), 495–508.

(196)     Jourdan, J.; Bureau, R.; Rochais, C.; Dallemagne, P. Drug Repositioning: A Brief Overview. J. Pharm. Pharmacol. 2020, 72 (9), 1145–1151.

(195)     Peronne, L.; Denarier, E.; Rai, A.; Prudent, R.; Vernet, A.; Suzanne, P.; Ramirez-Rios, S.; Michallet, S.; Guidetti, M.; Vollaire, J.; et al. Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells. Cancers (Basel). 2020, 12 (8), 2196.

(194)     Fersing, C.; Boudot, C.; Castera-Ducros, C.; Pinault, E.; Hutter, S.; Paoli-Lombardo, R.; Primas, N.; Pedron, J.; Seguy, L.; Bourgeade-Delmas, S.; Saquet, A.; Stigliani,J.-L.; Brossas, J.-Y.; Paris, L.; Valentin, A.; Wyllie, S.; Fairlamb, A.; Boutet-Robinet, E.; Corvaisier, S.; Since, M.; Malzert-Freon, A.; Destere, A.; Mazier, D.; Rathelot, P.; Courtioux, B.; Azas, N.; Verhaeghe, P.; Vanelle, P. 8-Alkynyl-3-Nitroimidazopyridines Display Potent Antitrypanosomal Activity against Both T. b. Brucei and Cruzi. Eur. J. Med. Chem. 2020, 202, 112558.

(193)     Dubost, E.; McErlain, H.; Babin, V.; Sutherland, A.; Cailly, T. Recent Advances in Synthetic Methods for Radioiodination. J. Org. Chem. 2020, 85 (13), 8300–8310.

(192)     Benabderrahmane, M.; Bureau, R.; Voisin-Chiret, A. S.; Sopkova-de Oliveira Santos, J. Insights into Mcl-1 Conformational States and Allosteric Inhibition Mechanism from Molecular Dynamics Simulations, Enhanced Sampling, and Pocket Crosstalk Analysis. J. Chem. Inf. Model. 2020, 60 (6), 3172–3187.

(191)    Hédou, D.; Voisin-Chiret, A. S. Br vs. TsO Chemoselective Suzuki-Miyaura Cross-Coupling Reaction on Nicotinaldehyde Moiety for the Preparation of 2,3,5-Trisubstituted Pyridines. European J. Org. Chem. 2020, 2020 (24), 3640–3649.

(190)     Valle-Casuso, J.-C.; Gaudaire, D.; Martin-Faivre, L.; Madeline, A.; Dallemagne, P.; Pronost, S.; Munier-Lehmann, H.; Zientara, S.; Vidalain, P.-O.; Hans, A. Replication of Equine Arteritis Virus Is Efficiently Suppressed by Purine and Pyrimidine Biosynthesis Inhibitors. Sci. Rep. 2020, 10 (1), 10100.

(189)     Percelay, S.; Since, M.; Lagadu, S.; Freret, T.; Bouet, V.; Boulouard, M. Antipsychotic Lurasidone: Behavioural and Pharmacokinetic Data in C57BL/6 Mice. Pharmacol. Biochem. Behav. 2020, 194 (May), 172933.

(188)    Rochais, C.; Lecoutey, C.; Hamidouche, K.; Giannoni, P.; Gaven, F.; Cem, E.; Mignani, S.; Baranger, K.; Freret, T.; Bockaert, J.; Rivera, S.; Boulouard, M.; Dallemagne, P.; Claeysen, S. Donecopride, a Swiss Army Knife with Potential against Alzheimer’s Disease. Br. J. Pharmacol. 2020, 177 (9), 1988–2005.

(187)     Garrido, A.; Lepailleur, A.; Mignani, S. M.; Dallemagne, P.; Rochais, C. HERG Toxicity Assessment: Useful Guidelines for Drug Design. Eur. J. Med. Chem. 2020, 195, 112290.

(186)     Pedron, J.; Boudot, C.; Brossas, J.-Y.; Pinault, E.; Bourgeade-Delmas, S.; Sournia-Saquet, A.; Boutet-Robinet, E.; Destere, A.; Tronnet, A.; Bergé, J.; Bonduelle, C.; Deraeve, C.; Pratviel, G.; Stigliani, J.-L.; Paris, L.; Mazier, D.; Corvaisier, S.; Since, M.; Malzert-Fréon, A.; Wyllie, S.; Milne, R.; Fairlamb, A. H.; Valentin, A.; Courtioux, B.; Verhaeghe, P. New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma Brucei and Cruzi. ACS Med. Chem. Lett. 2020, 11 (4), 464–472.

(185)     Adnet, T.; Groo, A.; Picard, C.; Davis, A.; Corvaisier, S.; Since, M.; Bounoure, F.; Rochais, C.; Pluart, L. Le; Dallemagne, P.; Malzert-Fréon, A. Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment. Pharmaceutics 2020, 12 (3), 251.

(184)     Lalut, J.; Payan, H.; Davis, A.; Lecoutey, C.; Legay, R.; Sopkova-de Oliveira Santos, J.; Claeysen, S.; Dallemagne, P.; Rochais, C. Rational Design of Novel Benzisoxazole Derivatives with Acetylcholinesterase Inhibitory and Serotoninergic 5-HT4 Receptors Activities for the Treatment of Alzheimer’s Disease. Sci. Rep. 2020, 10 (1), 3014.

(183)     Denis, C.; Sopková-de Oliveira Santos, J.; Bureau, R.; Voisin-Chiret, A. S. Hot-Spots of Mcl-1 Protein. J. Med. Chem. 2020, 63 (3), 928–943.

(182)     Dallemagne, P.; Rochais, C. Facing the Complexity of Alzheimer’s Disease. Future Med. Chem. 2020, 12 (3), 175–177.

(181)     Babin, V.; Tournier, B. B.; Davis, A.; Dubost, E.; Pigrée, G.; Lohier, J.; Reboul, V.; Cailly, T.; Bouillon, J.; Millet, P.; Fabis, F. Design of Iodinated Radioligands for SPECT Imaging of Central Human 5-HT4R Using a Ligand Lipophilicity Efficiency Approach. Bioorg. Chem. 2020, 96, 103582.

(180)     De Pascale, M.; Iacopetta, D.; Since, M.; Corvaisier, S.; Vie, V.; Paboeuf, G.; Hennequin, D.; Perato, S.; De Giorgi, M.; Sinicropi, M. S.; Sopkova-De Oliveira Santos, J.; Voisin-Chiret, A.S.; Malzert-Freon, A. Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes. ChemMedChem 2020, 15 (1), 136–154.

(179)     Gozzi, G. J.; Gonzalez, D.; Boudesco, C.; Dias, A. M. M.; Gotthard, G.; Uyanik, B.; Dondaine, L.; Marcion, G.; Hermetet, F.; Denis, C.; Hardy, L.; Suzanne, P.; Douhard, R.; Jego, G.; Dubrez, L.; Demidov, O.N.; Neiers, F.; Briand, L.; Sopková-de Oliveira Santos, J.; Voisin-Chiret, A.S.; Garrido, C. Selecting the First Chemical Molecule Inhibitor of HSP110 for Colorectal Cancer Therapy. Cell Death Differ. 2020, 27 (1), 117–129.

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Dernière modification : 18 mars 2021

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