EA 4258 | Centre d'études et de recherche sur le médicament de Normandie
Publications 2015
(120) Karila, D.; Freret, T.; Bouet, V.; Boulouard, M.; Dallemagne, P.; Rochais, C. Therapeutic Potential of 5-HT 6 Receptor Agonists. J. Med. Chem. 2015, 58, 7901–7912.
doi: 10.1021acs.jmedchem.5b00179
(119) de Fatima Pereira, M.; Rochais, C.; Dallemagne, P. Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities. Anticancer. Agents Med. Chem. 2015, 15, 1080–1091.
doi: 10.21741871520615666150520143600
(118) Kieffer, C.; Cohen, A.; Verhaeghe, P.; Paloque, L.; Hutter, S.; Castera-Ducros, C.; Laget, M.; Rault, S.; Valentin, A.; Rathelot, P.; Azas, N.; Vanelle, P. Antileishmanial Pharmacomodulation in 8-Nitroquinolin-2(1H)-One Series. Bioorg. Med. Chem. 2015, 23, 2377–2386.
doi: 10.1016j.bmc.2015.03.064
(117) Sinicropi, M. S.; Lappano, R.; Caruso, A.; Santolla, M. F.; Pisano, A.; Rosano, C.; Capasso, A.; Panno, A.; Lancelot, J. C.; Rault, S.; Saturnino, C.; Maggiolini, M. (6-Bromo-1,4-Dimethyl-9H-Carbazol-3-Yl-Methylene)-Hydrazine (carbhydraz) Acts as a GPER Agonist in Breast Cancer Cells. Curr. Top. Med. Chem. 2015, 15, 1035–1042.
doi: 10.21741568026615666150317221549
(116) Kieffer, C.; Cohen, A.; Verhaeghe, P.; Hutter, S.; Castera-Ducros, C.; Laget, M.; Remusat, V.; M’Rabet, M. K.; Rault, S.; Rathelot, P.; Azas, N.; Vanelle, P. Looking for New Antileishmanial Derivatives in 8-Nitroquinolin-2(1H)-One Series. Eur. J. Med. Chem. 2015, 92, 282–294.
doi: 10.1016j.ejmech.2014.12.056
(115) Quiedeville, A.; Boulouard, M.; Hamidouche, K.; Da Silva Costa-Aze, V.; Nee, G.; Rochais, C.; Dallemagne, P.; Fabis, F.; Freret, T.; Bouet, V. Chronic Activation of 5-HT4 Receptors or Blockade of 5-HT6 Receptors Improve Memory Performances. Behav. Brain Res. 2015, 293, 10–17.
doi: 10.1016/j.bbr.2015.07.020
(114) Cohen, A.; Suzanne, P.; Lancelot, J.-C.; Verhaeghe, P.; Lesnard, A.; Basmaciyan, L.; Hutter, S.; Laget, M.; Dumètre, A.; Paloque, L.; Deharo, E.; Crozet, M. D.; Rathelot, P.; Dallemagne, P.; Lorthiois, A.; Sibley, C. H.; Vanelle, P.; Valentin, A.; Mazier, D.; Rault, S.; Azas, N. Discovery of New Thienopyrimidinone Derivatives Displaying Antimalarial Properties toward Both Erythrocytic and Hepatic Stages of Plasmodium. Eur. J. Med. Chem. 2015, 95, 16–28.
doi: 10.1016/j.ejmech.2015.03.011
(113) Ursuegui, S.; Yougnia, R.; Moutin, S.; Burr, A.; Fossey, C.; Cailly, T.; Laayoun, A.; Laurent, A.; Fabis, F. A Biotin-Conjugated Pyridine-Based Isatoic Anhydride, a Selective Room Temperature RNA-Acylating Agent for the Nucleic Acid Separation. Org. Biomol. Chem. 2015, 13, 3625–3632.
doi: 10.1039/C4OB02636E
(112) Ugarte, W.; Boizumault, P.; Loudni, S.; Crémilleux, B.; Lepailleur, A. Soft Constraints for Pattern Mining. J. Intell. Inf. Syst. 2015, 44, 193–221.
doi: 10.1007/s10844-013-0281-4
(111) Ugarte, W.; Boizumault, P.; Crémilleux, B.; Lepailleur, A.; Loudni, S.; Plantevit, M.; Raïssi, C.; Soulet, A. Skypattern Mining: From Pattern Condensed Representations to Dynamic Constraint Satisfaction Problems. Artif. Intell. 2015.
doi: 10.1016/j.artint.2015.04.003
(110) Rochais, C.; Lecoutey, C.; Gaven, F.; Giannoni, P.; Hamidouche, K.; Hedou, D.; Dubost, E.; Genest, D.; Yahiaoui, S.; Freret, T.; Bouet, V.; Dauphin, F.; Sopkova-de Oliveira Santos, J.; Ballandonne, C.; Corvaisier, S.; Malzert-Freon, A.; Legay, R.; Boulouard, M.; Claeysen, S.; Dallemagne, P. Novel Multi-Target Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities as Potential Agents against Alzheimer’s Disease: The Design of Donecopride. J. Med. Chem. 2015, 58, 3172–3187.
doi: 10.1021/acs.jmedchem.5b00115
(109) Minguez, L.; Ballandonne, C.; Rakotomalala, C.; Dubreule, C.; Kientz-Bouchart, V.; Halm-Lemeille, M.-P. Transgenerational Effects of Two Antidepressants (Sertraline and Venlafaxine) on Daphnia Magna Life History Traits. Environ. Sci. Technol. 2015, 49, 1148–1155.
doi: 10.1021/es504808g
(108) Métivier, J.-P.; Lepailleur, A.; Buzmakov, A.; Poezevara, G.; Crémilleux, B.; Kuznetsov, S.; Le Goff, J.; Napoli, A.; Bureau, R.; Cuissart, B. Discovering Structural Alerts for Mutagenicity Using Stable Emerging Molecular Patterns. J. Chem. Inf. Model. 2015, 55, 925–940.
doi: 10.1021/ci500611v
(107) Larchanche, P.-E.; Ultré, V.; Le Broc, D.; Ballandone, C.; Furman, C.; Dallemagne, P.; Melnyk, P.; Carato, P. 6-Sulfonylbenzothiazolones as Potential Scaffolds for the Design of 5-HT6 Ligands. Eur. J. Med. Chem. 2015, 92, 807–817.
doi: 10.1016/j.ejmech.2015.01.052
(106) Hamdi, A.; Lesnard, A.; Suzanne, P.; Robert, T.; Miteva, M. A.; Pellerano, M.; Didier, B.; Ficko-Blean, E.; Lobstein, A.; Hibert, M.; Rault, S.; Morris, M. C.; Colas, P. Tampering with Cell Division by Using Small-Molecule Inhibitors of CDK-CKS Protein Interactions. ChemBioChem 2015, 16, 432–439.
doi: 10.1002/cbic.201402579
(105) Gloaguen, C.; Voisin-Chiret, A. S.; Sopkova-de Oliveira Santos, J.; Fogha, J.; Gautier, F.; De Giorgi, M.; Burzicki, G.; Perato, S.; Pétigny-Lechartier, C.; Simonin-Le Jeune, K.; Brotin, E.; Goux, D.; N’Diaye, M.; Lambert, B.; Louis, M.-H.; Ligat, L.; Lopez, F.; Juin, P.; Bureau, R.; Rault, S.; Poulain, L. First Evidence That Oligopyridines, α-Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-X L -Targeting Strategies. J. Med. Chem. 2015, 58, 1644–1668.
doi: 10.1021/jm500672y
(104) Fresneau, N.; Dumas, N.; Tournier, B. B.; Fossey, C.; Ballandonne, C.; Lesnard, A.; Millet, P.; Charnay, Y.; Cailly, T.; Bouillon, J.-P.; Fabis, F. Design of a Serotonin 4 Receptor Radiotracer with Decreased Lipophilicity for Single Photon Emission Computed Tomography. Eur. J. Med. Chem. 2015, 94, 386–396.
doi: 10.1016/j.ejmech.2015.03.017
(103) Fontaine, F.; Héquet, A.; Voisin-Chiret, A.-S.; Bouillon, A.; Lesnard, A.; Cresteil, T.; Jolivalt, C.; Rault, S. Boronic Species as Promising Inhibitors of the Staphylococcus Aureus NorA Efflux Pump: Study of 6-Substituted Pyridine-3-Boronic Acid Derivatives. Eur. J. Med. Chem. 2015, 95, 185–198.
doi: 10.1016/j.ejmech.2015.02.056
(102) Angelone, T.; Caruso, A.; Rochais, C.; Caputo, A. M.; Cerra, M. C.; Dallemagne, P.; Filice, E.; Genest, D.; Pasqua, T.; Puoci, F.; Saturnino, C.; Sinicropi, M. S.; El-Kashef, H. Indenopyrazole Oxime Ethers: Synthesis and β1-Adrenergic Blocking Activity. Eur. J. Med. Chem. 2015, 92, 672–681.
doi: 10.1016/j.ejmech.2015.01.037
doi: 10.1021acs.jmedchem.5b00179
(119) de Fatima Pereira, M.; Rochais, C.; Dallemagne, P. Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities. Anticancer. Agents Med. Chem. 2015, 15, 1080–1091.
doi: 10.21741871520615666150520143600
(118) Kieffer, C.; Cohen, A.; Verhaeghe, P.; Paloque, L.; Hutter, S.; Castera-Ducros, C.; Laget, M.; Rault, S.; Valentin, A.; Rathelot, P.; Azas, N.; Vanelle, P. Antileishmanial Pharmacomodulation in 8-Nitroquinolin-2(1H)-One Series. Bioorg. Med. Chem. 2015, 23, 2377–2386.
doi: 10.1016j.bmc.2015.03.064
(117) Sinicropi, M. S.; Lappano, R.; Caruso, A.; Santolla, M. F.; Pisano, A.; Rosano, C.; Capasso, A.; Panno, A.; Lancelot, J. C.; Rault, S.; Saturnino, C.; Maggiolini, M. (6-Bromo-1,4-Dimethyl-9H-Carbazol-3-Yl-Methylene)-Hydrazine (carbhydraz) Acts as a GPER Agonist in Breast Cancer Cells. Curr. Top. Med. Chem. 2015, 15, 1035–1042.
doi: 10.21741568026615666150317221549
(116) Kieffer, C.; Cohen, A.; Verhaeghe, P.; Hutter, S.; Castera-Ducros, C.; Laget, M.; Remusat, V.; M’Rabet, M. K.; Rault, S.; Rathelot, P.; Azas, N.; Vanelle, P. Looking for New Antileishmanial Derivatives in 8-Nitroquinolin-2(1H)-One Series. Eur. J. Med. Chem. 2015, 92, 282–294.
doi: 10.1016j.ejmech.2014.12.056
(115) Quiedeville, A.; Boulouard, M.; Hamidouche, K.; Da Silva Costa-Aze, V.; Nee, G.; Rochais, C.; Dallemagne, P.; Fabis, F.; Freret, T.; Bouet, V. Chronic Activation of 5-HT4 Receptors or Blockade of 5-HT6 Receptors Improve Memory Performances. Behav. Brain Res. 2015, 293, 10–17.
doi: 10.1016/j.bbr.2015.07.020
(114) Cohen, A.; Suzanne, P.; Lancelot, J.-C.; Verhaeghe, P.; Lesnard, A.; Basmaciyan, L.; Hutter, S.; Laget, M.; Dumètre, A.; Paloque, L.; Deharo, E.; Crozet, M. D.; Rathelot, P.; Dallemagne, P.; Lorthiois, A.; Sibley, C. H.; Vanelle, P.; Valentin, A.; Mazier, D.; Rault, S.; Azas, N. Discovery of New Thienopyrimidinone Derivatives Displaying Antimalarial Properties toward Both Erythrocytic and Hepatic Stages of Plasmodium. Eur. J. Med. Chem. 2015, 95, 16–28.
doi: 10.1016/j.ejmech.2015.03.011
(113) Ursuegui, S.; Yougnia, R.; Moutin, S.; Burr, A.; Fossey, C.; Cailly, T.; Laayoun, A.; Laurent, A.; Fabis, F. A Biotin-Conjugated Pyridine-Based Isatoic Anhydride, a Selective Room Temperature RNA-Acylating Agent for the Nucleic Acid Separation. Org. Biomol. Chem. 2015, 13, 3625–3632.
doi: 10.1039/C4OB02636E
(112) Ugarte, W.; Boizumault, P.; Loudni, S.; Crémilleux, B.; Lepailleur, A. Soft Constraints for Pattern Mining. J. Intell. Inf. Syst. 2015, 44, 193–221.
doi: 10.1007/s10844-013-0281-4
(111) Ugarte, W.; Boizumault, P.; Crémilleux, B.; Lepailleur, A.; Loudni, S.; Plantevit, M.; Raïssi, C.; Soulet, A. Skypattern Mining: From Pattern Condensed Representations to Dynamic Constraint Satisfaction Problems. Artif. Intell. 2015.
doi: 10.1016/j.artint.2015.04.003
(110) Rochais, C.; Lecoutey, C.; Gaven, F.; Giannoni, P.; Hamidouche, K.; Hedou, D.; Dubost, E.; Genest, D.; Yahiaoui, S.; Freret, T.; Bouet, V.; Dauphin, F.; Sopkova-de Oliveira Santos, J.; Ballandonne, C.; Corvaisier, S.; Malzert-Freon, A.; Legay, R.; Boulouard, M.; Claeysen, S.; Dallemagne, P. Novel Multi-Target Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities as Potential Agents against Alzheimer’s Disease: The Design of Donecopride. J. Med. Chem. 2015, 58, 3172–3187.
doi: 10.1021/acs.jmedchem.5b00115
(109) Minguez, L.; Ballandonne, C.; Rakotomalala, C.; Dubreule, C.; Kientz-Bouchart, V.; Halm-Lemeille, M.-P. Transgenerational Effects of Two Antidepressants (Sertraline and Venlafaxine) on Daphnia Magna Life History Traits. Environ. Sci. Technol. 2015, 49, 1148–1155.
doi: 10.1021/es504808g
(108) Métivier, J.-P.; Lepailleur, A.; Buzmakov, A.; Poezevara, G.; Crémilleux, B.; Kuznetsov, S.; Le Goff, J.; Napoli, A.; Bureau, R.; Cuissart, B. Discovering Structural Alerts for Mutagenicity Using Stable Emerging Molecular Patterns. J. Chem. Inf. Model. 2015, 55, 925–940.
doi: 10.1021/ci500611v
(107) Larchanche, P.-E.; Ultré, V.; Le Broc, D.; Ballandone, C.; Furman, C.; Dallemagne, P.; Melnyk, P.; Carato, P. 6-Sulfonylbenzothiazolones as Potential Scaffolds for the Design of 5-HT6 Ligands. Eur. J. Med. Chem. 2015, 92, 807–817.
doi: 10.1016/j.ejmech.2015.01.052
(106) Hamdi, A.; Lesnard, A.; Suzanne, P.; Robert, T.; Miteva, M. A.; Pellerano, M.; Didier, B.; Ficko-Blean, E.; Lobstein, A.; Hibert, M.; Rault, S.; Morris, M. C.; Colas, P. Tampering with Cell Division by Using Small-Molecule Inhibitors of CDK-CKS Protein Interactions. ChemBioChem 2015, 16, 432–439.
doi: 10.1002/cbic.201402579
(105) Gloaguen, C.; Voisin-Chiret, A. S.; Sopkova-de Oliveira Santos, J.; Fogha, J.; Gautier, F.; De Giorgi, M.; Burzicki, G.; Perato, S.; Pétigny-Lechartier, C.; Simonin-Le Jeune, K.; Brotin, E.; Goux, D.; N’Diaye, M.; Lambert, B.; Louis, M.-H.; Ligat, L.; Lopez, F.; Juin, P.; Bureau, R.; Rault, S.; Poulain, L. First Evidence That Oligopyridines, α-Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-X L -Targeting Strategies. J. Med. Chem. 2015, 58, 1644–1668.
doi: 10.1021/jm500672y
(104) Fresneau, N.; Dumas, N.; Tournier, B. B.; Fossey, C.; Ballandonne, C.; Lesnard, A.; Millet, P.; Charnay, Y.; Cailly, T.; Bouillon, J.-P.; Fabis, F. Design of a Serotonin 4 Receptor Radiotracer with Decreased Lipophilicity for Single Photon Emission Computed Tomography. Eur. J. Med. Chem. 2015, 94, 386–396.
doi: 10.1016/j.ejmech.2015.03.017
(103) Fontaine, F.; Héquet, A.; Voisin-Chiret, A.-S.; Bouillon, A.; Lesnard, A.; Cresteil, T.; Jolivalt, C.; Rault, S. Boronic Species as Promising Inhibitors of the Staphylococcus Aureus NorA Efflux Pump: Study of 6-Substituted Pyridine-3-Boronic Acid Derivatives. Eur. J. Med. Chem. 2015, 95, 185–198.
doi: 10.1016/j.ejmech.2015.02.056
(102) Angelone, T.; Caruso, A.; Rochais, C.; Caputo, A. M.; Cerra, M. C.; Dallemagne, P.; Filice, E.; Genest, D.; Pasqua, T.; Puoci, F.; Saturnino, C.; Sinicropi, M. S.; El-Kashef, H. Indenopyrazole Oxime Ethers: Synthesis and β1-Adrenergic Blocking Activity. Eur. J. Med. Chem. 2015, 92, 672–681.
doi: 10.1016/j.ejmech.2015.01.037
Dernière modification : 7 avril 2016
Université de Caen Normandie
CERMN · Centre d’études et de recherche sur le médicament de Normandie
Boulevard Becquerel | 14032 Caen Cedex | France
CERMN · Centre d’études et de recherche sur le médicament de Normandie
Boulevard Becquerel | 14032 Caen Cedex | France
