EA 4258 | Centre d'études et de recherche sur le médicament de Normandie
Publications 2013
(77) Tomasina, J.; Malzert-Freon, A.; Giffard, F.; Brotin, E.; Louis, M.-H.; Abeilard, E.; Rault, S.; Gauduchon, P.; Poulain, L. Sensitization of Ovarian Carcinoma Cells to Bcl-xL-Targeting Strategies through Indirect Modulation of Mcl-1 Activity by MR22388, a Molecule of the Tripentone Family. J. Ovarian Res. 2013, 6, 38–44.
(76) Tomasina, J.; Lheureux, S.; Gauduchon, P.; Rault, S.; Malzert-Fréon, A. Nanocarriers for the Targeted Treatment of Ovarian Cancers. Biomaterials, 2013, 34, 1073–1101.
(75) Tomasina, J.; Poulain, L.; Abeilard, E.; Giffard, F.; Brotin, E.; Carduner, L.; Carreiras, F.; Gauduchon, P.; Rault, S.; Malzert-Fréon, A. Rapid and Soft Formulation of Folate-Functionalized Nanoparticles for the Targeted Delivery of Tripentone in Ovarian Carcinoma. Int. J. Pharm. 2013, 458, 197–207.
(74) Szalata, C.; Szymoniak, J.; Fabis, F.; Butt-Gueulle, S.; Rault, S.; Bertus, P.; Gérard, S.; Sapi, J. Cyclopropyl-Tryptamine Analogues: Synthesis and Biological Evaluation as 5-HT6 Receptor Ligands. ChemMedChem 2013, 8, 70–73.
(73) Setifi, Z.; Setifi, F.; El Ammari, L.; El-Ghozzi, M.; Sopková-de Oliveira Santos, J.; Merazig, H.; Glidewell, C. Poly[[chlorido(1,10-Phenanthroline-κ2N,N')copper(II)]-μ3-1,1,3,3-Tetracyano-2-Ethoxypropenido-κ3N:N':N'']: Coordination Polymer Sheets Linked into Bilayers by Hydrogen Bonds. Acta Crystallogr. Sect. C Struct. Chem. 2013, 70, 19–22.
(72) Rochais, C.; Rault, S.; Dallemagne, P. Advances in Anticancer Agents in Medicinal Chemistry; Prudhomme, M., Ed.; BENTHAM SCIENCE PUBLISHERS, 2013; Vol. 2.
(71) Rochais, C.; Cresteil, T.; Perri, V.; Jouanne, M.; Lesnard, A.; Rault, S.; Dallemagne, P. MR22388, a Novel Anti-Cancer Agent with a Strong FLT-3 ITD Kinase Affinity. Cancer Lett. 2013, 331, 92–98.
(70) Perato, S.; Fogha, J.; Sebban, M.; Voisin-Chiret, A. S.; Sopkova-De Oliveira Santos, J.; Oulyadi, H.; Rault, S. Conformation Control of Abiotic α-Helical Foldamers. J. Chem. Inf. Model. 2013, 53, 2671–2680.
(69) Lepailleur, A.; Poezevara, G.; Bureau, R. Automated Detection of Structural Alerts (Chemical Fragments) in (eco)Toxicology. Comput. Struct. Biotechnol. J. 2013, 5, 1–8.
(68) Kieffer, C.; Verhaeghe, P.; Primas, N.; Castera-Ducros, C.; Gellis, A.; Rosas, R.; Rault, S.; Rathelot, P.; Vanelle, P. Sonogashira Cross-Coupling Reaction in 4-Chloro-2- Trichloromethylquinazoline Series Is Possible despite a Side Dimerization Reaction. Tetrahedron 2013, 69, 2987–2995.
(67) Jourdan, J.-P.; Rochais, C.; Legay, R.; Sopkova de Oliveira Santos, J.; Dallemagne, P. An Unusual Boron Tribromide-Mediated, One-Pot Bromination/cyclization Reaction. Application to the Synthesis of a Highly Strained cyclopenta[1,3]cyclopropa[1,2-B]pyrrolizin-8-One. Tetrahedron Lett. 2013, 54, 1133–1136.
(66) Johansson, H.; Cailly, T.; Thomsen, A. R. B.; Bräuner-Osborne, H.; Pedersen, D. S. Synthesis of the Calcilytic Ligand NPS 2143. Beilstein J. Org. Chem. 2013, 9, 1383–1387.
(65) Genest, D.; Rochais, C.; Lecoutey, C.; Oliveira Santos, J. S.; Ballandonne, C.; Butt-Gueulle, S.; Legay, R.; Since, M.; Dallemagne, P. Design, Synthesis and Biological Evaluation of Novel Indano- and Thiaindano-Pyrazoles with Potential Interest for Alzheimer’s Disease. Medchemcomm 2013, 4, 925–931.
(64) Fresneau, N.; Cailly, T.; Fabis, F.; Bouillon, J. P. Synthesis of Substituted Diazino[c]quinolin-5(6H)-Ones, Diazino[c]isoquinolin-6(5H)-Ones, Diazino[c]naphthyridin-6(5H)-Ones and Diazino[c]naphthyridin-5(6H)-Ones. Tetrahedron 2013, 69, 5393–5400.
(63) Fontenelle, C. Q.; Wang, Z.; Fossey, C.; Cailly, T.; Linclau, B.; Fabis, F. Design of Fluorinated 5-HT4R Antagonists: Influence of the Basicity and Lipophilicity toward the 5-HT4R Binding Affinities. Bioorganic Med. Chem. 2013, 21, 7529–7538.
(62) Dulin, F.; Halm-Lemeille, M.-P.; Lozano, S.; Lepailleur, A.; Santos, J. S. O.; Rault, S.; Bureau, R. Corrigendum to “Interpretation of Honeybees Contact Toxicity Associated to Acetylcholinesterase Inhibitors” [Ecotoxicol. Environ. Saf. 79 (2012) 13–21]. Ecotoxicol. Environ. Saf. 2013, 90, 183–184.
(61) Di Poi, C.; Evariste, L.; Serpentini, A.; Halm-Lemeille, M. P.; Lebel, J. M.; Costil, K. Toxicity of Five Antidepressant Drugs on Embryo-Larval Development and Metamorphosis Success in the Pacific Oyster, Crassostrea Gigas. Environ. Sci. Pollut. Res. Int. 2013, 21, 13302–13314.
(60) De Giorgi, M.; Voisin-Chiret, a S.; Rault, S. Targeting the BH3 Domain of Bcl-2 Family Proteins. A Brief History from Natural Products to Foldamers as Promising Cancer Therapeutic Avenues. Curr. Med. Chem. 2013, 20, 2964–2978.
(59) Cheikh, N.; Villemin, D.; Bar, N.; Lohier, J. F.; Choukchou-Braham, N.; Mostefa-Kara, B.; Sopkova, J. A Serendipitous Conversion of Enaminolactone Nitriles with Primary Amines: A New Synthesis of Substituted 2-Aminopyridine Derivatives. Tetrahedron 2013, 69, 1234–1247.
(58) Brossard, D.; Zhang, Y.; Haider, S. M.; Sgobba, M.; Khalid, M.; Legay, R.; Duterque-Coquillaud, M.; Galera, P.; Rault, S.; Dallemagne, P.; Moslemi, S.; El Kihel, L. N-Substituted Piperazinopyridylsteroid Derivatives as Abiraterone Analogues Inhibit Growth and Induce pro-Apoptosis in Human Hormone-Independent Prostate Cancer Cell Lines. Chem. Biol. Drug Des. 2013, 82, 620–629.
(76) Tomasina, J.; Lheureux, S.; Gauduchon, P.; Rault, S.; Malzert-Fréon, A. Nanocarriers for the Targeted Treatment of Ovarian Cancers. Biomaterials, 2013, 34, 1073–1101.
(75) Tomasina, J.; Poulain, L.; Abeilard, E.; Giffard, F.; Brotin, E.; Carduner, L.; Carreiras, F.; Gauduchon, P.; Rault, S.; Malzert-Fréon, A. Rapid and Soft Formulation of Folate-Functionalized Nanoparticles for the Targeted Delivery of Tripentone in Ovarian Carcinoma. Int. J. Pharm. 2013, 458, 197–207.
(74) Szalata, C.; Szymoniak, J.; Fabis, F.; Butt-Gueulle, S.; Rault, S.; Bertus, P.; Gérard, S.; Sapi, J. Cyclopropyl-Tryptamine Analogues: Synthesis and Biological Evaluation as 5-HT6 Receptor Ligands. ChemMedChem 2013, 8, 70–73.
(73) Setifi, Z.; Setifi, F.; El Ammari, L.; El-Ghozzi, M.; Sopková-de Oliveira Santos, J.; Merazig, H.; Glidewell, C. Poly[[chlorido(1,10-Phenanthroline-κ2N,N')copper(II)]-μ3-1,1,3,3-Tetracyano-2-Ethoxypropenido-κ3N:N':N'']: Coordination Polymer Sheets Linked into Bilayers by Hydrogen Bonds. Acta Crystallogr. Sect. C Struct. Chem. 2013, 70, 19–22.
(72) Rochais, C.; Rault, S.; Dallemagne, P. Advances in Anticancer Agents in Medicinal Chemistry; Prudhomme, M., Ed.; BENTHAM SCIENCE PUBLISHERS, 2013; Vol. 2.
(71) Rochais, C.; Cresteil, T.; Perri, V.; Jouanne, M.; Lesnard, A.; Rault, S.; Dallemagne, P. MR22388, a Novel Anti-Cancer Agent with a Strong FLT-3 ITD Kinase Affinity. Cancer Lett. 2013, 331, 92–98.
(70) Perato, S.; Fogha, J.; Sebban, M.; Voisin-Chiret, A. S.; Sopkova-De Oliveira Santos, J.; Oulyadi, H.; Rault, S. Conformation Control of Abiotic α-Helical Foldamers. J. Chem. Inf. Model. 2013, 53, 2671–2680.
(69) Lepailleur, A.; Poezevara, G.; Bureau, R. Automated Detection of Structural Alerts (Chemical Fragments) in (eco)Toxicology. Comput. Struct. Biotechnol. J. 2013, 5, 1–8.
(68) Kieffer, C.; Verhaeghe, P.; Primas, N.; Castera-Ducros, C.; Gellis, A.; Rosas, R.; Rault, S.; Rathelot, P.; Vanelle, P. Sonogashira Cross-Coupling Reaction in 4-Chloro-2- Trichloromethylquinazoline Series Is Possible despite a Side Dimerization Reaction. Tetrahedron 2013, 69, 2987–2995.
(67) Jourdan, J.-P.; Rochais, C.; Legay, R.; Sopkova de Oliveira Santos, J.; Dallemagne, P. An Unusual Boron Tribromide-Mediated, One-Pot Bromination/cyclization Reaction. Application to the Synthesis of a Highly Strained cyclopenta[1,3]cyclopropa[1,2-B]pyrrolizin-8-One. Tetrahedron Lett. 2013, 54, 1133–1136.
(66) Johansson, H.; Cailly, T.; Thomsen, A. R. B.; Bräuner-Osborne, H.; Pedersen, D. S. Synthesis of the Calcilytic Ligand NPS 2143. Beilstein J. Org. Chem. 2013, 9, 1383–1387.
(65) Genest, D.; Rochais, C.; Lecoutey, C.; Oliveira Santos, J. S.; Ballandonne, C.; Butt-Gueulle, S.; Legay, R.; Since, M.; Dallemagne, P. Design, Synthesis and Biological Evaluation of Novel Indano- and Thiaindano-Pyrazoles with Potential Interest for Alzheimer’s Disease. Medchemcomm 2013, 4, 925–931.
(64) Fresneau, N.; Cailly, T.; Fabis, F.; Bouillon, J. P. Synthesis of Substituted Diazino[c]quinolin-5(6H)-Ones, Diazino[c]isoquinolin-6(5H)-Ones, Diazino[c]naphthyridin-6(5H)-Ones and Diazino[c]naphthyridin-5(6H)-Ones. Tetrahedron 2013, 69, 5393–5400.
(63) Fontenelle, C. Q.; Wang, Z.; Fossey, C.; Cailly, T.; Linclau, B.; Fabis, F. Design of Fluorinated 5-HT4R Antagonists: Influence of the Basicity and Lipophilicity toward the 5-HT4R Binding Affinities. Bioorganic Med. Chem. 2013, 21, 7529–7538.
(62) Dulin, F.; Halm-Lemeille, M.-P.; Lozano, S.; Lepailleur, A.; Santos, J. S. O.; Rault, S.; Bureau, R. Corrigendum to “Interpretation of Honeybees Contact Toxicity Associated to Acetylcholinesterase Inhibitors” [Ecotoxicol. Environ. Saf. 79 (2012) 13–21]. Ecotoxicol. Environ. Saf. 2013, 90, 183–184.
(61) Di Poi, C.; Evariste, L.; Serpentini, A.; Halm-Lemeille, M. P.; Lebel, J. M.; Costil, K. Toxicity of Five Antidepressant Drugs on Embryo-Larval Development and Metamorphosis Success in the Pacific Oyster, Crassostrea Gigas. Environ. Sci. Pollut. Res. Int. 2013, 21, 13302–13314.
(60) De Giorgi, M.; Voisin-Chiret, a S.; Rault, S. Targeting the BH3 Domain of Bcl-2 Family Proteins. A Brief History from Natural Products to Foldamers as Promising Cancer Therapeutic Avenues. Curr. Med. Chem. 2013, 20, 2964–2978.
(59) Cheikh, N.; Villemin, D.; Bar, N.; Lohier, J. F.; Choukchou-Braham, N.; Mostefa-Kara, B.; Sopkova, J. A Serendipitous Conversion of Enaminolactone Nitriles with Primary Amines: A New Synthesis of Substituted 2-Aminopyridine Derivatives. Tetrahedron 2013, 69, 1234–1247.
(58) Brossard, D.; Zhang, Y.; Haider, S. M.; Sgobba, M.; Khalid, M.; Legay, R.; Duterque-Coquillaud, M.; Galera, P.; Rault, S.; Dallemagne, P.; Moslemi, S.; El Kihel, L. N-Substituted Piperazinopyridylsteroid Derivatives as Abiraterone Analogues Inhibit Growth and Induce pro-Apoptosis in Human Hormone-Independent Prostate Cancer Cell Lines. Chem. Biol. Drug Des. 2013, 82, 620–629.
Dernière modification : 13 septembre 2015
Université de Caen Normandie
CERMN · Centre d’études et de recherche sur le médicament de Normandie
Boulevard Becquerel | 14032 Caen Cedex | France
CERMN · Centre d’études et de recherche sur le médicament de Normandie
Boulevard Becquerel | 14032 Caen Cedex | France
